Fibroblasts in the dermis are responsible for the production of collagen to form the connective tissue, as well as for assisting in the wound healing of the skin. When these fibroblasts either age or encounter too many harmful oxidative stresses, such as UV light and pollution, they become senescent. Senescent cells are also called “zombie cells” for the following reason: whilst they no longer divide, they are also far from being dead. Senescent cells block an intracellular pathway that promotes their apoptosis (i.e. cell death) in order to prevent their own elimination. Moreover, they continue to secrete signaling molecules that promote inflammation and can influence surrounding cells into also becoming senescent. In younger tissue, senescent cells are usually cleared by the immune system.
Long-Term Effects on the Skin
In aged skin and skin that has been exposed to consistent stress, the large number of senescent cells can no longer be cleared by the immune system without help and they therefore accumulate. The resulting chronic inflammation exacerbates the aging process by promoting collagen degradation, which leads to a lack of skin elasticity. In terms of stressed scalps, the inflammation can lead to irritated and red scalps.
Senolytics – Clearing the Tissue of “Zombie Cells”
The formation and accumulation of senescent cells is considered to be one of the hallmarks of aging. As a result, eliminating senescent cells has emerged as a promising anti-aging therapy in the medical field in the past few years. A novel concept known as “senolytics” helps to clear tissues of senescent cells in order to reduce inflammation and rejuvenate the tissue. Notably, healthy cells are not affected by senolytic agents as they specifically target senescent cells. For the first time, the concept of senolytics has been applied in the cosmetic field. Alpine Rose Active was shown to act as a senolytic by reducing the number of senescent cells while not affecting the number of healthy cells.
Alpine Rose Active Combines Strong Cell Protecting and Senolytic Activities
Thanks to its high concentration of compounds with cell protecting activity, Alpine Rose Active inhibits the formation of carbonylated proteins and therefore protects the skin against the formation of premature senescent cells. Where cellular senescence has already occurred, Alpine Rose Active can help to clear these cells from the tissue thanks to its senolytic activity for rejuvenated skin from the inside out.
Alpine Rose Active
Alpine Rose active has been used in multiple Skin Management System skin care products.
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