ProBioBalance CLR™ NP consists of postbiotic bifido cultures, suspended and disintegrated in a biologically active milk-based matrix. It supplies the skin cells with nutritive elements and allows for the activation of detoxification processes. The metabolic activity of skin cells is increased, the skin’s immune system strengthened and protected against environmental stress.
Nutrients supplied to keratinocytes are digested by lysosomes after endocytosis. ProBioBalance CLR™ NP supplies keratinocytes with vital nutrients, activating lysosomal activity (1). The metabolic activity of keratinocytes is increased.
Toxic cellular waste can be disposed of and made available for reuse by autophagy. In this process autophagosomes, containing cellular waste, fuse with lysosomes, allowing for its digestion. LC3B serves as a marker for monitoring autophagosome development. ProBioBalance CLR™ NP promotes an increase in LC3B, indicating that it activates autophagy and, therefore, cellular detox processes, waste disposal and reuse.
Defined skin areas were treated with SDS to induce redness. Decrease in redness was then recorded for skin areas treated twice daily with 5% ProBioBalance CLR™ NP. On Day 9 the SDS treatment was repeated and the development of skin redness recorded. ProBioBalance CLR™ NP was both shown to reduce the visible signs of skin irritation, and the skin was clearly more resistant against external stresses compared to untreated and placebo.
ProBioBalance CLR™ NP has been applied in multiple Skin Management System products.
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